Abstract: Cenozoic terrestrial sediment directly overlies on Mesozoic marine limestone of Triassic System in the central uplift region of South Yellow Sea. The difference in velocity is quite big between Cenozoic formations and Mesozoic-Paleozoic marine formations. The special geological characteristics enable sea surface, sea bottom and Cenozoic bottom sediment to form three strong wave impedance differential interfaces, leading to the strongest multi-reflection and screening energy propagation downward. Based on the geological conditions in this region and seismic acquisition experience in the past, this article analyzes the seismic reflection characteristics of Mesozoic-Paleozoic in South Yellow Sea and makes wave equation forward modeling. The design for seismic acquisition is made on the basis of the efforts to analyze the reasons why the imaging quality is poor. The double geophone tow-cable acquisition technique is used for seismic data acquisition at this time. Finally, comparison ismade between the results of acquisition at this time and the results achieved in 2002, coming up with the orientation for further efforts.