Abstract: Yanchang Formation of Honghe Oilfield in Ordos Basin is a lithologic oil reservoir. The main horizons are characterized as low porosity, low permeability and strong heterogeneity, difficult for exploration and development. Distribution of favorable sand bodies is a key factor to restrict exploration and development of Honghe Oilfield. Conventional wave impedance inversion is difficult to predict distribution of reservoirs because the differences of wave impedance from the surrounding mudstone cap rock are very small. Take Chang-81, the main oil layer of Honghe Oilfield, for instance, the natural gamma curve and neutron porosity curve are used to reconstruct a lithologic indicator curve to effectively differentiate sandstone from mudstone. The Chang-81 sand body is predicted on the basis of multi-well constrained sparse pulse inversion and geological statistical inversion. Good results have been achieved, providing the convincing basis for deployment of horizontal wells.