Abstract: The core problem of low-permeability oil & gas reservoirs' exploration and exploitation is to heighten the output of single well, so as to declining the production cost. Recently, with the continuous improvement of reservoir reconstruction technology and further research on Xiazijie region in northwestern Junggar Basin, it is tackled the key problems focusing mainly on reconstruction technology for high-pressure and low-permeability reservoirs in this area, and on the basis of analysis the early fractured effect of neighbor wells, starting with the content of clay minerals in reservoirs, the reconstruction technique such as fracture fluid mixing,fracturing scale and modeling software application are chosen particularly, the reservoir difficulties of high-pressure and low permeability has been resolved and used it to guide site production and obtained a important breakthrough, which will provide new exploration thoughts to deepen exploration in northwestern slope of Junggar Basin .