Abstract: Chepaizi-Mosuowan paleo-uplift in Junggar Basin belongs to southwest-eastnorth Yanshan paleo-uplift, its area is more than 20000 sq. km. In the deep part of Chepaizi-Mosuowan paleo-uplift at present, low-amplitude anticlines and nose structures also exist; however, the shallowstructures are simple, fault is not developed. The evolution of Chepaizi-Mosuowan paleo-uplift can be divided into five stages, i.e. uplift formation stage, slowly growing stage, violently developing stage ,subtle and burial stage as well as reconstructing and adjusting stage. Chepaizi- Mosuowan paleo-uplift have provided with the conditions to form the various subtle traps such as lithologic and stratigraphic traps, and good settings for oil/gas migration and accumulation, which are favorable to generate the large-scale and regional oil/gas reservoirs inside the basin.