Abstract: Erlian Basin in Huabei Oilfield features in polycyclic sequence, multiple sets of source-reservoir-cap rock assemblages, diversified sandstone traps, and multi-period accumulation. So how to improve research and prediction on sand-shale interbed efficiently becomes an important issue for conducting reservoir prediction research. This paper discusses the geophysics response characteristics of “strong amplitude and high continuity”, which increases the multiplicity of reservoir prediction, and puts forward corresponding countermeasures. It is pointed out that the sand-shale interbed research area focuses on improving resolution, under the constraint of isochronous stratigraphic framework, combining with forward modeling techniques, proceeding from theoretic model, and using the method integrating frequency broadening, frequency dividing, and seismic inversion to conduct comprehensive research. Application shows that countermeasures have brought about good results, providing important theoretic basis and technical support for well deployment and reserves submission in Erlian Basin.