Abstract: Karst topography is common in Guizhong mountainous area in Guangxi. Near surface and subsurface structure are complex and varied in the area. Most of rock is carbonate rock directly cropping up with development of karst and fractures, causing a number of disadvantages, such as poor conditions for excitation and acceptance, low original signal-to-noise ratio, serious static correction problems and difficult structural imaging. Based the study and experiment, the bin stack information of adjacent gathers is used for wide line survey method and all kind of interference is suppressed effectively while the quality of seismic section is improved substantially. Under the special geological conditions of Guizhong mountainous areas, the crooked wide-line acquisition technique is an effective method to suppress interference and improve the signal-to-noise ratio of seismic section. With good results for acquisition achieved in application, this method can be widely used in the similar low signal-to-noise ratio regions.