Abstract: Uplift structure is the large-scale positive structural unit in the sedimentary basin. It is the main place for oil and gas accumulation. Formation and development of uplift is a complicated dynamic process owing to the multi-cycle superimposed development of the sedimentary basin. The different geological structures in the different stages of the uplift, such as , the sedimentary stage, the (oil and gas) migration and accumulation stage, the adjustment stage, and shaping stage, determine the geological environment for oil and gas generation,migration, accumulation and distribution. Therefore, the dynamics for uplift structural development holds the key to analysis of oil and gas basin structure. From the view of palaeostructural analysis, this paper analyzes the structural evolutional history of Mosuowan Uplift in Junggar Basin. Mosuowan Uplift is a large-scale uplift developed under the background of the Carboniferous "basement" uplift and subject to the Permian structural activities. The uplift comes under strong remoulding from the later period of Middle Jurassic to Late Jurassic after the stable subsidence and burial in the Xishanyao Formation sedimentary period in Triassic-Middle Jurassic. Afterwards, the uplift has experienced another stable subsidence in Early Cretaceous and the oscillatory activities in Late Cretaceous to Early Tertery, and in Later Tertery started to tilt southward with the rapid subsidence of Changji Sag on the southern side. Mosuowan Uplift has gone through six geo-dynamic development stages - preliminary stage, development stage, burial stage, remoulding stage, adjustment stage and reshaping stage. It currently becomes a large-scale anticline with the large buried depth. It has the superior conditions for hydrocarbon accumulation.