Abstract: In the Kelasu structural belt of the Kuqa Depression in the Tarim Basin, the burial depth of reservoir is deep and the geological conditions are complex, which leads to great challenges in drilling and completion operations, such as well control safety, well construction time efficiency, engineering quality, single well production increase and so on. In view of these key technical issues, which restrict the exploration and development process, a set of technical processes of geology-engineering integration with geo-mechanics as a bridge has been established, forming a series of methods, such as well location selection, well trajectory optimization, pre-drilling formation pressure prediction, borehole stability prediction, completion and stimulation optimization, and sand and water production prediction in development. Geological research, engineering design, and on-site operation, are organized and integrated into a collaborative system to solve engineering issues and achieve “3 improvements” in the Kelasu structural belt: improvements in drilling speed, improvements in quality, and improvements in production. The drilling success rate of development wells is 100%, complex drilling issues in single wells are reduced by 40% on average, and well control safety is effectively guaranteed. After stimulation, the average open gas flow of a single well increased from 68×104 m3/d to 279×104 m3/d. Gas productivity of 150×108 m3/a in the eastern Kelasu area has been successfully established and contributed to the major discovery of a trillion square meters of gas reservoirs in the western Kelasu area, which has provided technologies and accumulated experience for efficient development of ultra-deep complex reservoirs.